Research Activity:

In the fields of Organic and Bioorganic Chemistry

• Preparation of quality collections of heterocyclic and natural compounds with biological interest.

• New scaffolds for inhibitors of TK (cMet, Abl, Src), p53, HDAC, tubulin,       topoisomerase I and II.

• Chemistry of Natural Products: Camptothecin, Podophillotoxin, Thiocolchicine, Colchicine, Evodiamine, Vinca Alkaloids (vincristine, vinblastine), Makaluvamine, Piperidine Alkaloids, Epothilone A.

• Application of “Flow Chemistry” to “Medicinal Chemistry” and to the Synthesis of Natural Products

• Enatioselective synthesis of nitrogen containing compounds

• Preparation of hybrid compounds

• Multiple interaction with biological targets involved in the biology of cancer
• Preparation of prodrugs
• Dynamic Combinatorial Libraries